![]() With the development of computed tomography (CT) technology, the clinical detection rate of small pulmonary nodules (SPNs) is increasing. ![]() Our study preliminarily suggested that the technique using sodium alginate-Fe 3O 4 magnetic gel to locate small pulmonary nodules with guidance of X-ray, and to search for them under an applied magnetic field during the operation is safe and feasible. All tissues retained good histologic morphology and no magnetic fluid was observed. Pathological analysis showed the gel had a clear boundary without diffusion of magnetic fluid. The shape and position of the gel had not changed when viewed under X-ray. The gel was formed after injection and drew lung tissue to form a protrusion from the lung surface under the applied magnetic field. Observe tissues morphology of heart, liver, spleen, and kidney in the same way. Thoracotomy was performed to excise tissue containing the gel, and hematoxylin–eosin staining was used to observe the tissue on postoperative days 1, 3, 5, and 7. Imaging changes to the lung were observed under X-ray daily. In long-term localization, the gel was injected under X-ray guidance. In short-term localization, a coaxial double-cavity puncture needle was applied to inject the gel into the lung after thoracotomy, and a pursuit magnet made of Nd-Fe-B permanent magnetic materials was used to attract the gel representing location of the nodule. A magnetic gel was used as a tracer magnet, mixed as sodium alginate-Fe 3O 4 magnetic fluid and calcium gluconate solution. Rabbits were used as the experimental objects. ![]() We introduce a novel magnetic gel for small pulmonary nodules localization in rabbit model, and furtherly evaluate its safety and feasibility. However, deficiencies of complications and success rates exist. Many methods are used to locate preoperative small pulmonary nodules.
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